Running Title: Relationship of Extreme CIN with Breast Cancer Prognosis 1 Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer
نویسندگان
چکیده
1 Cancer Research UK London Research Institute, London, WC2A 3LY, United Kingdom. 2 Barts Cancer Institute, Queen Mary University of London, London, EC1B 6BQ, UK. University of Applied Sciences Koblenz/RheinAhrCampus, Südallee 2, 53424 Remagen, Germany. The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom Leeds Institute of Molecular Medicine, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK. Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. Center for Biological Sequence Analysis, Technical University of Denmark, DK-2800 Lyngby, Denmark.
منابع مشابه
Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer.
BACKGROUND Chromosomal instability (CIN) is thought to be associated with poor prognosis in solid tumors; however, evidence from preclinical and mouse tumor models suggest that CIN may paradoxically enhance or impair cancer cell fitness. Breast cancer prognostic expression signature sets, which reflect tumor CIN status, efficiently delineate outcome in estrogen receptor ER-positive breast cance...
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Chromosomal instability (CIN) is associated with poor prognosis in human cancer. However, in certain animal tumor models elevated CIN negatively impacts upon organism fitness, and is poorly tolerated by cancer cells. To better understand this seemingly contradictory relationship between CIN and cancer cell biological fitness and its relationship with clinical outcome, we applied the CIN70 expre...
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